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Systematic reviews

Interventions to achieve long-term weight loss in obese older people: A systematic review and meta-analysis

1 Section of Ageing and Health, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK2 Health Services Research Unit, University of Aberdeen, Aberdeen, UK Address correspondence to: M. Witham. Tel: (+44) 1382 632436; Fax: (+44) 1382 660675. Email: ...

Interventions to achieve long-term weight loss in obese older people

Systematic ReviewA systematic review and meta-analysisMiles D. Witham1 and Alison Avenell2 1 Section of Ageing and Health, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK2 Health Services Research Unit, University of Aberdeen, Aberdeen, UK Ad ...

Physical exercise training interventions for children and young adults during and after treatment for childhood cancer

Braam, K.I., et al To evaluate the effect of a physical exercise training intervention (at home, at a physical therapy centre, or hospital based) on the physical fitness of children with cancer, in comparison with the physical fitness in a care as usual c ...

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus

Hemmingsen, B., et al To assess the effects of sulphonylurea monotherapy versus placebo, no intervention or other antidiabetic interventions for patients with T2DM Sulphonylureas are widely used for patients with type 2 diabetes mellitus. Sulphonylureas l ...

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Lawrie, T.A., et al To assess the efficacy and safety of PLD in women with relapsed epithelial ovarian cancer (EOC) The choice of chemotherapy in women with relapsed epithelial ovarian cancer (EOC) is influenced by the duration of the platinum-free interv ...

Psychosocial interventions for patients with head and neck cancer

Semple, C., et al To assess the effectiveness of psychosocial interventions to improve quality of life and psychosocial well-being for patients with head and neck cancer There is a steady rise in the number of people being diagnosed with head and neck can ...

Post-surgical chemotherapy versus surgery alone for resectable gastric cancer

Diaz-Nieto, R., et al To determine whether post-surgical chemotherapy should be used routinely in resectable gastric cancer Stomach cancer is the second leading cause of cancer-related death worldwide. Surgery is the only curative treatment offered to pat ...

Perioperative nutrition interventions for women with ovarian cancer

Billson, HA., et al This review was conducted to assess the effects of nutrition interventions during the perioperative period for women with ovarian cancer Women who have ovarian cancer, (a cancer which develops in the two organs (ovaries) that produce e ...

Systemic treatments for the prevention of venous thrombo-embolic events in paediatric cancer patients with tunnelled central venous catheters

Schoot, RA., et al To investigate the effects of preventive systemic treatments in paediatric cancer patients with tunnelled CVCs on (a)symptomatic VTE Children with cancer are at higher risk of thrombosis than children without cancer. This is a result of ...

Sulthiame add-on therapy for epilepsy

Milburn-McNulty, P., et al To compare the efficacy and side-effect profile of sulthiame as add-on therapy compared with placebo or another antiepileptic drug Epilepsy is a common neurological condition which is characterised by recurrent seizures. The maj ...

Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia

Declercq, T., et al To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia in community or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older people with deme ...

Statins for the primary prevention of cardiovascular disease

Taylor, F., et al Prevention of cardiovascular disease Cardiovascular disease (CVD), which comprises heart attacks (myocardial infarction), angina and strokes, is ranked as the number one cause of mortality and is a major cause of morbidity world wide. Hi ...

The Epidemiology of Low Back Pain in Primary Care

Kent, P. M. and Keating, J. L. Current knowledge on prevalence, activity limitation (disability), care-seeking, natural history and clinical course, treatment outcome, and costs of low back pain (LBP) This descriptive review provides a summary of the prev ...

Surgery for Obesity

Colquitt JL, Picot J, Loveman E, Clegg AJ Management of overweight and obesity Obesity is associated with many health problems and a higher risk of death. Bariatric (weight loss) surgery for obesity is usually only considered when all other treatments hav ...

Weight reduction for primary prevention of stroke in adults with overweight or obesity

Curioni C, André C, Veras R Management of overweight and obesity Rigorous scientific evidence linking overweight or obesity with increased risk for stroke is missing. Overweight and obesity are important public health problems and are associated with many ...

Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Norris, S.L. et al Weight management Obesity is closely related to type 2 diabetes and long-term weight reduction is an important part of the care delivered to obese persons with diabetes. The objective of this review is to assess the efficacy of pharmaco ...

Pentoxifylline for diabetic retinopathy

de Jesus, C.C.L. et al Diabetic retinopathy There is increasing evidence that capillary occlusion plays an important part in the development of diabetic retinopathy. Disaggregants, such as pentoxyfilline may influence the outcome and progression of diabet ...

Vitamin C and superoxide dismutase (SOD) for diabetic retinopathy

de Jesus, C.C.L. et al Effects of vitamin C and superoxide dismutase on diabetic retinopathy There is increasing evidence that diabetic retinopathy is caused by the action of free radicals. Radical scavengers like vitamin C and superoxide dismutase (SOD) ...

Debridement of diabetic foot ulcers

Edwards, J. and Stapley, S. Diabetic foot ulcers Foot ulceration is thought to affect 15% of people with diabetes at some time in their lives. Debridement is widely regarded as an effective intervention to speed up ulcer healing. The most effective method ...

Foam dressings for healing diabetic foot ulcers

Durnville, J.C., Deshpande, S., O'Meara S. and Speak, K. Diabetic foot ulcers Foot ulcers in people with diabetes are a prevalent and serious global health issue. Dressings form a key part of ulcer treatment, with clinicians and patients having many ...

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