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Research and evaluation

Cancer Incidence trends to 1993-2013 with projections to 2035

Monitoring trends in cancer incidence is essential if high quality cancer services are to be maintained and resourced. Trends for all cancers (excluding non-melanoma skin cancer- NMSC) along with the most common cancers are analysed in detail. Additionall ...

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis

During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to in ...

First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer

Nivolumab has been associated with longer overall survival than docetaxel among patients with previously treated nonâ?"small-cell lung cancer (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with ...

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Question  What are the breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers and are they related to family history of cancer and mutation position? Findings  From a prospective cohort of 9856 mutation carriers, mainly ascertained through ...

The relationship between statins and breast cancer prognosis varies by statin type and exposure time: A meta-analysis

Background:Breast cancer is the most common cancer in females. The effects of statins on breast cancer prognosis have long been controversial, so it is important to investigate the relationship between statin type, exposure time, and breast cancer prognos ...

Tracking the Evolution of Non-Small-Cell Lung Cancer

Among patients with nonâ?"small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to cl ...

Design and preliminary analysis of a vaginal inserter for speculum-free cervical cancer screening

Objective Cervical cancer screening usually requires use of a speculum to provide a clear view of the cervix. The speculum is one potential barrier to screening due to fear of pain, discomfort and embarrassment. The aim of this paper is to present and dem ...

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility. In cells bearing such heterozygous mutations, we find that a cellular metabolite and ubiquitous environmental toxin, formaldehyde, stalls and destabilizes DNA ...

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed th ...

Dietary sugar intake increases liver tumor incidence in female mice

Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens. However, the mechanism linking diet to increased liver tumorigenesis remains unclear in the context of whether tumorigenesis is se ...

Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data

Background Thrombocytosis (raised platelet count) is an emerging risk marker of cancer, but the association has not been fully explored in a primary care context. Aim To examine the incidence of cancer in a cohort of patients with thrombocytosis, to deter ...

Roll your own cigarettes in Ireland: key patterns and trends.

The findings of new research provide an insight into RYO (Roll your own) smoking consumption patterns in Ireland. It provides the first detailed examination of RYO consumption from the HSEâ?Ts National Tobacco Control Office monthly survey of smoking prev ...

Health technology assessment (HTA) of smoking cessation interventions.

The Health Information and Quality Authority (HIQA) carried out a health technology assessment (HTA) of smoking cessation interventions in Ireland to examine the clinical effectiveness, safety and cost-effectiveness of smoking cessation interventions, as ...

Human papillomavirus (HPV) immunisation programme- Factsheet for healthcare professionals

This factsheet provides information for health professionals on the Humanpapillomavirus(HPV) immunisation programme for girls aged 12-13 years. Public Health Agency Virus, Infection This factsheet provides information for health professionals on the Human ...

Diabetic eye screening

Public Health Agency Diabetes People with diabetes who should receive diabetic eye screening every year Chronic Conditions Conditions Diabetes Research and Evaluation Other Outputs http://www.publichealthagency.org/node/2955 © Public 26 March 2017 Poster ...

Diabetic eye screening

This 'belly' poster was developed by the PHA with the Northern Ireland Diabetic Eye Screening Programme for screening clinics to display the date and time of eye screening. Public Health Agency Diabetes This 'belly' poster was develope ...

No Smoking Day 2017

No Smoking Day 2017 resource. Public Health Agency Smoking, Tobacco No Smoking Day 2017 resource. Chronic Conditions Conditions Cancer Research and Evaluation Other Outputs http://www.publichealthagency.org/node/2938 © Public 1 January 2017 Poster Public ...

No Smoking Day 2017

No Smoking Day 2017 resource. Public Health Agency Tobacco, Smoking No Smoking Day 2017 resource. Chronic Conditions Conditions Cancer Research and Evaluation Other Outputs http://www.publichealthagency.org/node/2937 © Public 1 January 2017 Poster Public ...

Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer: supporting personalised screening

Background: Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of br ...

Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe

We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), wh ...

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