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Health Impact Assessment

Smoking prevalence by age-group, deprivation quintile, health and social care trust 2010/11- 2015/16

This information has been produced from the health survey Northern Ireland and issued 10th January 2017. Department of Health (Northern Ireland) Statistical reports, DoH statistics and research, Department of Health commissioned surveys This information h ...

Smoking in the home and cars 2015/16

This information has been produced from the health survey Northern Ireland and issued 30th January 2017. Department of Health (Northern Ireland) Statistical reports, DoH statistics and research, Department of Health commissioned surveys This information h ...

Northern Ireland waiting time statistics: cancer waiting times June to December 2016

Presents information on waiting times for patients accessing cancer services at hospitals in Northern Ireland during each quarter. Department of Health (Northern Ireland) Statistical reports, DoH statistics and research, Hospital waiting times statistics ...

Cancer Incidence trends to 1993-2013 with projections to 2035

Monitoring trends in cancer incidence is essential if high quality cancer services are to be maintained and resourced. Trends for all cancers (excluding non-melanoma skin cancer- NMSC) along with the most common cancers are analysed in detail. Additionall ...

National Cancer Strategy 2017-2026

This National Cancer Strategy 2017-2026 aims to meet the needs of cancer patients in Ireland for the next decade. Rapid advances have been made in cancer diagnostics and treatments. The objective is to ensure that cancer services respond to both the chall ...

Understanding the heterogeneity of cervical screening non-participants: data from a national sample of UK women

BACKGROUND: Uptake of cervical cancer screening in the United Kingdom (UK) is falling year on year, and a more sophisticated understanding of non-participation may help design interventions to reverse this trend. This study ascertained the prevalence of d ...

National Cancer Strategy 2017-2026

5.7.2017 This National Cancer Strategy 2017-2026 aims to meet the needs of cancer patients in Ireland for the next decade. Rapid advances have been made in cancer diagnostics and treatments. The objective is to ensure that cancer services respond to both ...

Urban Green Space Interventions and Health: A Review of Impacts and Effectivness

World Health Organization (WHO) Urban Health, Cities, Environment, Spoace, Obesity, Cardiovascular Health, Well-being, Equity Interventions on green space in urban settings can help address public health issues related to obesity, cardiovascular effects, ...

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis

During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to in ...

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed ...

First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer

Nivolumab has been associated with longer overall survival than docetaxel among patients with previously treated nonâ?"small-cell lung cancer (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with ...

Sam68 Allows Selective Targeting of Human Cancer Stem Cells

Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling, are a ...

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Question  What are the breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers and are they related to family history of cancer and mutation position? Findings  From a prospective cohort of 9856 mutation carriers, mainly ascertained through ...

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed ...

Circulating Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.

Biomarkers for a more precise patient care are needed in metastatic prostate cancer (mPC). We have reported a Phase II trial (TOPARP-A) of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib in mPC, demonstrating antitumor activity associating with ...

Equality and Human Rights Consultation- NICE TA- Trastuzumab Emtansine for Treating HER2 Positive Advanced Breast Cancer after Trastuzumab and a Taxane (Review of TA371)

NICE guidance is designed and developed for the NHS in England and is therefore not automatically applicable to Northern Ireland. On 1 July 2006 the Department established links with NICE whereby all technology appraisals and clinical guidelines published ...

Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration

Phytocannabinoids possess anticancer activity when used alone, and a number have also been shown to combine favourably with each other in vitro in leukaemia cells to generate improved activity. We have investigated the effect of pairing cannabinoids and a ...

The relationship between statins and breast cancer prognosis varies by statin type and exposure time: A meta-analysis

Background:Breast cancer is the most common cancer in females. The effects of statins on breast cancer prognosis have long been controversial, so it is important to investigate the relationship between statin type, exposure time, and breast cancer prognos ...

Tracking the Evolution of Non-Small-Cell Lung Cancer

Among patients with nonâ?"small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to cl ...

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design.   The New E ...

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