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Systematic reviews

'Human' insulin versus animal insulin in people with diabetes mellitus

Richter, B. and Neisis, G. Insulin treatment Human insulin was introduced for the routine treatment of diabetes mellitus in the early 1980s without adequate comparison of efficacy to animal insulin preparations. First reports of altered hypoglycaemia awar ...

A systematic review of the effectiveness of lifestyle interventions for the prevention of type 2 diabetes mellitus (T2DM) in routine practice.

10.14655/743983-900692 Public Health England Lifestyle interventions, Prevention, Type 2 diabetes mellitus This document updates and extends a previously conducted systematic review and meta-analysis assessing the effectiveness of ‘real-world’ interventio ...

Adult consequences of late adolescent alcohol consumption: a systematic review of cohort studies.

Background Alcohol is responsible for a significant portion of the global burden of disease. There is widespread concern reported in the media and other sources about drinking trends among young people, particularly heavy episodic or â?obingeâ? drinking. ...

Advocacy interventions to reduce or eliminate violence and promote the physical and psychosocial wellbeing of women who experience intimate partner abuse

Ramsay, J. et al. Partner abuse, Violence, Domestic violence Intimate partner abuse is common in all societies and damages the health of survivors and their children in the short and long term. Advocacy may decrease the impact of this abuse on women' ...

Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose

Van da Laar, F. et al Alpha-glucosidase inhibitors, Blood glucose Alpha-glucosidase inhibitors (AGIs) reduce blood glucose levels and may thus prevent type 2 diabetes and cardiovascular disease in patients with impaired glucose tolerance (IGT). These poss ...

Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema

Parravano, M., Menchini, F. and Virgili, G. Diabetic macular oedema (DMO), Diabetic retinopathy, Vision, Therapy Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy. The retina at the macula thickens and this can cause gradual l ...

Antibiotics for brain abscesses in people with cyanotic congenital heart disease

Lumbiganon, P. and Chaikitpinyo, A. Heart disease Brain abscess is a focal, intracerebral infection that begins as a localized area of brain infection and develops into a collection of pus surrounded by a well-vascularized capsule. People with cyanotic co ...

Antibiotics for exacerbations of chronic obstructive pulmonary disease

Vollenweider, D., et al Antibiotics, Acute COPD exacerbation,Treatment failure, Primary outcome, Mortality, Adverse events, Length of hospital stay Chronic obstructive pulmonary disease (COPD) is a chronic condition, often caused by smoking, which affects ...

Artichoke leaf extract for treating hypercholesterolaemia

Wider, B. et al Hypercholesterolaemia Hypercholesterolaemia is directly associated with an increased risk for coronary heart disease and other sequelae of atherosclerosis. Artichoke leaf extract (ALE) has been implicated in lowering cholesterol levels. Wh ...

Behavioral, Psychological, Educational, and Vocational Interventions to Facilitate Employment Outcomes for Cancer Survivors: A Systematic Review

Fong C.J. et al Cancer, Survivor In the United States, an estimated 1.5 million people are diagnosed annually with some type of cancer (American Cancer Society, 2011). Work is an important stabilizing factor for cancer survivors (Arnold, 1999). De Boer an ...

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder in children and adolescents

O'Kearney, R.T., Anstey, K., von Sanden, C. andHunt, A. Obsessive-compulsive disorder (OCD) Background This is an update of a Cochrane Review first published in The Cochrane Library in Issue 4, 2006. Obsessive-compulsive disorder (OCD) in children an ...

Burden of major musculoskeletal conditions

Woolf AD, Pfleger B Musculoskeletal condition, Osteoarthritis, Rheumatoid arthritis, Osteoporosis Musculoskeletal conditions are a major burden on individuals, health systems, and social care systems, with indirect costs being predominant. This burden has ...

Chinese herbal medicines for hypercholesterolemia

Lan Lui, Z. et al Chinese medicine Hypercholesterolemia is an important key contributory factor for ischemic heart disease and is associated with age, high blood pressure, a family history of hypercholesterolemia, and diabetes. Chinese herbal medicines ha ...

Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose

Grant, S.J. et al Herbal medicines Around 308 million people worldwide are estimated to have impaired glucose tolerance (IGT); 25% to 75% of these will develop diabetes within a decade of initial diagnosis. At diagnosis, half will have tissue-related dama ...

Cognitive rehabilitation for executive dysfunction in adults with stroke or other adult non-progressive acquired brain damage

Chung, C.S.Y., et al Cognitive rehabilitation, Executive Dysfunction, Adults, Stroke, Non-progressive acquired brain injury Executive function is the term used to describe the brain processes that we use to organise ourselves and solve problems. Executive ...

Complex interventions for preventing diabetic foot ulceration

Dorresteijn, J.A.N., Knegsman, D.M.W. and Valk, G.D. Diabetic foot ulcers Ulceration of the feet, which can lead to the amputation of feet and legs, is a major problem for people with diabetes mellitus, and can cause substantial economic burden. Single pr ...

Computer-based diabetes self-management interventions for adults with type 2 diabetes mellitus

Pal, k., et al Health status, Quality of life, Diabetes, Self-management Diabetes is one of the commonest long-term medical conditions, affecting around 347 million adults worldwide. Around 90% of them have type 2 diabetes and are at significant risk of d ...

Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus

Masso, M.L. et al Type 1 diabetes Type 1 diabetes is a metabolic disorder resulting from a defect in insulin secretion. Onset of type 1 diabetes mellitus may occur at any age and it is one of the most common chronic diseases of childhood and adolescence. ...

Database of Abstracts of Reviews of Effects (DARE)

Centre for Review and Dissemination OBESITY, OVERWEIGHT DARE contains 15,000 abstracts of systematic reviews including over 6,000 quality assessed reviews and details of all Cochrane reviews and protocols. The database focuses on the effects of interventi ...

Debridement of diabetic foot ulcers

Edwards, J. and Stapley, S. Diabetic foot ulcers Foot ulceration is thought to affect 15% of people with diabetes at some time in their lives. Debridement is widely regarded as an effective intervention to speed up ulcer healing. The most effective method ...

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